Inside the formulas
Cycle System and Cramp Patch are built one decision at a time. Here is what each ingredient is there to do, the exact form we chose, how much is in every dose, and why that is worth paying for.
Inside Urinary Duo
Urinary Duo pairs a Botanical capsule built around 36 mg of cranberry PACs with a Probiotic capsule carrying a named strain, LR06. Here is what each ingredient does, the form we chose, and why.
Start with what you feel
Choose a symptom to see what can be going on in your body, which formula is built for it, and the ingredients doing the work.
In your body
Before and during your period, the lining of the uterus releases prostaglandins. These compounds make the muscle of the uterus contract so it can shed the lining. Stronger contractions are what you feel as cramps, low in the abdomen and often in the lower back.
Why the formulation matters
Cramps get two lines of support. Fennel, ginger and yarrow, three of the most studied botanicals for period cramps, sit in the capsules you take across your nine-day window. Cramp Patch adds comfort you apply exactly where you feel it, the moment it hits.
Research context. Fennel, ginger and yarrow have each been studied in randomized trials for menstrual cramp pain, mostly as single ingredients and often at higher doses than in our multi-ingredient formula. See the research by ingredient
Where we work on it
Key ingredients
In your body
In the second half of your cycle, shifting estrogen and progesterone change how your body holds on to fluid. In the days before a period that can show up as bloating, a tighter waistband, puffy ankles or tender breasts.
Why the formulation matters
Fennel is the Day capsule's largest botanical at 100 mg, with a long history of use for bloating and digestive comfort. Chaste tree is among the most studied botanicals for premenstrual symptoms, bloating and breast fullness included. Magnesium comes as bisglycinate, a chelated form chosen over cheaper magnesium oxide.
Research context. Magnesium has been studied for premenstrual fluid retention at 200 mg a day. Ours is 30 mg of magnesium inside a broader Night formula. See the research by ingredient
Where we work on it
Key ingredients
In your body
Estrogen and progesterone fall in the days before your period. That drop is linked to irritability, low mood, tension and a shorter fuse, even in a week when nothing else has changed.
Why the formulation matters
Chaste tree is the backbone: its premenstrual research is among the strongest of any botanical, across irritability, mood and anger. Rhodiola is an adaptogen studied for stress-related fatigue. Vitamin B6 is in its active P5P form, in both capsules, so your body can use it without converting it first.
Research context. Chaste tree trials used specific extracts at 20 to 40 mg a day. Ours is a 4:1 dry extract at 40 mg. See the research by ingredient
Where we work on it
Key ingredients
In your body
Body temperature runs higher in the second half of your cycle, and sleep often gets lighter and more broken in the days before a period. Night-time cramps make it harder to wind down.
Why the formulation matters
Everything calming sits in the Night capsule, so it lands in your evening, not your morning. Passionflower and lemon balm both have sleep-quality data from double-blind trials. Lemon balm is standardized to 2.5% rosmarinic acid, so every batch is held to the same marker.
Research context. Sleep trials used passionflower at 90 to 700 mg and lemon balm at 300 to 600 mg. In the Night capsule they work alongside each other, with magnesium and essential oils. See the research by ingredient
Where we work on it
Key ingredients
Why PMS is never just one symptom
After ovulation, estrogen and progesterone rise. In the days before your period, both fall. Cramps, bloating, irritability and broken sleep tend to cluster in that same stretch, which is why a single-ingredient fix rarely covers it.
Cycle System is timed to it. Start seven days before your period and continue through the second day. If your cycle is irregular, start when your symptoms start.
The PMS Bundle
Cycle System covers the nine days, morning and evening. Cramp Patch covers the moments inside them when cramps break through. Together they are the most complete way we know to get through PMS.
Mornings
Comfort, mood and function for the day ahead. Built around fennel, chaste tree and rhodiola, with turmeric, ginger and the active form of B6.
1 capsule each morning
Fennel 100 mg, rhodiola 100 mg, turmeric 50 mg, chaste tree 40 mg, ginger 10 mg, black pepper 5 mg, vitamin B6 5 mg, vitamin D3 2.5 mcg
Evenings
Calm, recovery and sleep. Yarrow for cramp comfort, with passionflower, lemon balm and magnesium for winding down.
1 capsule each evening
Yarrow 80 mg, lemon balm 80 mg, passionflower 50 mg, magnesium 30 mg, vitamin B6 5 mg, lavender oil 2 mg, sweet orange oil 2 mg
When cramps hit
Comfort exactly where you feel it. A thin botanical patch for your lower abdomen or lower back that stays on through your day.
Wear up to 12 hours
Boswellia 50 mg, arnica 30 mg, ginger 12 mg, eucalyptus oil 5 mg, orange peel oil 3 mg, lavender oil 2.5 mg, menthyl lactate 2 mg, bisabolol 1 mg, per patch
On harder days in the window you can take 2 Day capsules in the morning and 2 Night capsules in the evening. Never more than 4 capsules in 24 hours. This is a nine-day routine each cycle, not an everyday supplement.
One Cycle System box (14 Day + 14 Night capsules) and one Cramp Patch pouch (6 patches), in one order.
$52 one-time
Save $9 compared with buying them separately
Three Cycle System boxes and three Cramp Patch pouches, delivered together, with a Welcome Kit in your first shipment. $124.80 every three months, $41.60 a month. Ships free. Renews automatically every three months until you cancel.
Why three cycles: take Cycle System in the same nine-day window each cycle and note how cramps, bloating, mood and sleep compare. Three cycles gives you a fair comparison, not a verdict on one.
Prefer one product? Cycle System or Cramp Patch. Your first order is covered by our 30-day first-order guarantee. View terms
Inside a cramp
Taken by mouth, across the nine days. Fennel, ginger and yarrow have been studied for period cramp pain; turmeric is paired with black pepper for absorption. Ingredient research
Worn on the skin, where you feel it. Arnica, boswellia and ginger with cooling eucalyptus and menthyl lactate, for comfort at the application site. Product design
Inside Cramp Patch
Three traditional topical botanicals at the core, two cooling agents so you feel it in place, and three aromatics and skin-comfort ingredients. Amounts are per patch.
Boswellia50 mg, AKBA-enrichedThe largest active in the patch
6 patches per pouch. Each 3 x 5 in, worn up to 12 hours on the lower abdomen or lower back.
Eucalyptus oil5 mgFresh, cooling sensation
Arnica30 mgTraditional topical comfort
ML
Menthyl lactate2 mgSustained cooling, softer than menthol
Ginger CO2 extract12 mgWarmth at the application site
Orange peel oil3 mgPart of the scent profile
Cramp Patch is formulated in France and manufactured in the United States. It provides comfort where it is applied. For external use only.
Purposeful formulas. Clearly disclosed doses. Documented manufacturing controls and batch testing. Cycle System and Urinary Duo are formulated and manufactured in France. Cramp Patch is formulated in France and made in the United States.
Start with what you feel
In your body
Most urinary discomfort starts when bacteria from the gut reach the urethra and attach to the lining of the urinary tract. Once attached, they are harder to flush out. The result is the urgency, frequency and burning you know too well.
Why the formulation matters
Cranberry is standardized so every Botanical capsule delivers 36 mg of PACs, the compounds the research measures. Heather and uva ursi are traditional European botanicals for urinary comfort. LR06 lives in its own capsule, so live cultures and botanical extracts never share a shell.
Research context. Cranberry PACs have been studied for making it harder for bacteria to attach to the urinary tract lining. A 2024 meta-analysis found results only at 36 mg of PACs a day or more. See the research by ingredient
Where we work on it
Key ingredients
The BioTandem System
Live cultures and botanical extracts do not belong in the same capsule. So Urinary Duo keeps them apart: a Botanical capsule built around cranberry PACs, and a Probiotic capsule with a named strain. One of each, daily, for up to seven days.
Named to the strain, because two strains of the same species can behave very differently.
Urinary Duo is formulated and manufactured in France. Take 1 Botanical + 1 Probiotic capsule daily for up to seven days; the pack allows up to 2 + 2 daily, never more than 4 capsules in 24 hours.
Pairings
50 mg + 5 mg, same Day capsule
Curcumin on its own is poorly absorbed. Piperine, from black pepper, helps more of it reach your bloodstream. A small amount with a specific job.
50 mg + 80 mg + 30 mg, Night capsule
The evening trio. Two sleep-studied botanicals with magnesium for muscle relaxation, kept out of your morning.
92 mg combined, per patch
The core of Cramp Patch. Three traditional topical botanicals, with cooling oils so you can feel the patch in place.
The ingredient library
All 19 ingredients in Cycle System and Cramp Patch: the role each one plays, the exact form we chose, our amount next to the amount studied, and the reason behind it. Open any card for the botanical name and the research.
All five ingredients in Urinary Duo: the role each one plays, the exact form we chose, our amount next to the amount studied, and the reason behind it. Open any card for the botanical name and the research.
Research summaries describe published studies of individual ingredients, often at different doses or in different extracts. They are not trials of Kaia Relief products, and a studied amount is not an instruction to take more.
Cramp and bloating support
The Day capsule's largest botanical. Fennel has some of the most cited research for period cramps, and a long history of use for bloating and digestive comfort.
Foeniculum vulgare, fruit
A 2020 meta-analysis of 12 randomized trials found fennel comparable to conventional pain relievers for menstrual pain, and better than placebo.
Irritability, mood and premenstrual tension
One of the most studied botanicals for premenstrual symptoms. Concentrated 4:1 and dosed within the range used in the research.
Vitex agnus-castus, fruit
A meta-analysis of double-blind trials found chaste tree more effective than placebo for premenstrual symptoms. A landmark trial reported improvements in irritability, mood, anger, breast fullness and bloating over three cycles.
Stress resilience and daytime stamina
An adaptogen for the fatigue and short fuse of the late cycle. It sits in the Day capsule, where energy support belongs.
Rhodiola rosea, root
Human trials have studied rhodiola for stress-related fatigue and mental performance. This research is not specific to PMS.
Comfort, and a healthy inflammatory response
Standardized to 95% curcuminoids, the compounds the research measures. Paired with black pepper extract in the same capsule, because curcumin alone is poorly absorbed.
Curcuma longa, root
Double-blind trials found curcumin reduced overall premenstrual symptom scores versus placebo over three cycles.
Absorption partner for turmeric
Piperine slows the breakdown of curcumin, so more of it is absorbed. Small amount, specific job.
Piper nigrum, fruit
The effect of piperine on curcumin absorption is well documented.
Cramp and abdominal comfort
Ginger appears twice, in the form suited to each job: a 10:1 concentrate in the capsule, and a concentrated CO2 extract in the patch for warmth at the application site.
Zingiber officinale, rhizome
Meta-analyses find ginger more effective than placebo for menstrual discomfort. In Cycle System it is one part of a multi-ingredient formula.
Mood and normal nervous system function
We use P5P, the form your body uses directly, rather than pyridoxine hydrochloride, the common form, which has to be converted first.
Pyridoxal 5'-phosphate
A systematic review of nine trials found vitamin B6 helped premenstrual symptoms. Here it is a supporting nutrient within the formula.
Nutritional support
Sourced from lichen, a plant, rather than lanolin from sheep's wool.
Cholecalciferol, from lichen
Research linking vitamin D to premenstrual symptoms mainly concerns correcting a deficiency. Here it is nutritional support.
Cramp comfort through the evening
A botanical with a long traditional use for menstrual discomfort, concentrated 4:1. It keeps cramp support going after the Day capsule.
Achillea millefolium, aerial parts
A double-blind trial found yarrow reduced menstrual pain scores versus placebo over two cycles.
Calm and sleep quality
Standardized to 2.5% rosmarinic acid, so every batch is held to the same active marker.
Melissa officinalis, leaf
Recent double-blind trials report improved sleep quality and reduced anxiety.
Winding down and sleep quality
Anchors the Night capsule's sleep profile, alongside lemon balm and magnesium.
Passiflora incarnata, aerial parts
Double-blind trials found passionflower improved sleep quality versus placebo.
Muscle relaxation and premenstrual fluid balance
Magnesium bound to glycine, chosen over magnesium oxide, the cheaper form. In the Night capsule, because magnesium supports normal muscle function and relaxation.
Magnesium bisglycinate
A double-blind crossover trial found 200 mg of magnesium a day eased premenstrual fluid-retention symptoms (bloating, swelling, breast tenderness) by the second cycle. Ours works within a broader Night formula.
Aromatic calm
A sensory layer in the evening capsule and in the patch. Included at aromatic amounts, not clinical ones, and we label it that way.
Lavandula angustifolia
Oral lavender oil has been studied for anxiety. In our formulas it is an aromatic contribution.
Aromatic layer
Blended with lavender in the Night capsule's essential-oil blend, and part of the patch's scent profile.
Citrus sinensis, peel
Included as an aromatic ingredient. We make no clinical claim for it at this amount.
Topical comfort support
We chose an AKBA-enriched extract over generic boswellia. AKBA is one of the resin's key active compounds.
Boswellia serrata, resin
Topical boswellia has been studied for joint comfort. There is no landmark trial of a multi-botanical menstrual cramp patch, and we do not claim one.
Traditional topical comfort
Used on the skin for centuries for muscle comfort. One of the three core botanicals in Cramp Patch.
Arnica montana, flower
Evidence for arnica comes mainly from topical use for muscle and joint comfort, not menstrual cramps specifically.
Cooling sensation
A fresh, cooling sensation that lets you know the patch is in place.
Eucalyptus globulus, leaf
Included for sensation at the application site. We make no clinical claim for it.
Long-lasting cooling
A gentle, sustained cooling sensation without the sharpness of raw menthol.
Menthyl lactate
Included for sensation. We make no clinical claim for it.
Skin comfort under the patch
Included for the comfort of the skin you wear the patch on, for up to 12 hours.
Alpha-bisabolol
Included for skin comfort at the application site. We make no clinical claim for it.
Urinary tract support
Standardized so each capsule delivers 36 mg of PACs, the daily level identified in a 2024 meta-analysis. Not cranberry juice powder with unmeasured content.
Vaccinium macrocarpon, fruit
PACs have been studied for making it harder for bacteria to attach to the urinary tract lining. A 2024 meta-analysis of 10 trials found results only at 36 mg of PACs a day or more.
Traditional urinary comfort
A traditional European botanical for urinary comfort, recognized in the French Pharmacopoeia. Concentrated 4:1.
Calluna vulgaris, aerial parts
Heather is supported by traditional use in European phytotherapy rather than modern clinical trials.
Urinary tract comfort
Standardized to its key compound, arbutin. Recognized by the European Medicines Agency for traditional urinary use, and suited to a short routine.
Arctostaphylos uva-ursi, leaf
Uva ursi has a European Medicines Agency herbal monograph for traditional use. It is intended for short-term use.
Normal mucous membranes
Riboflavin supports the maintenance of normal mucous membranes and energy metabolism.
Riboflavin
Established nutritional science.
The probiotic side of Urinary Duo
Named to the strain. In its own capsule and individually blister-sealed, to protect live cultures from moisture, air and the botanicals.
Lactobacillus rhamnosus LR06
L. rhamnosus strains have been studied for urinary and vaginal microbiome support. Strain-specific urinary trials for LR06 are limited.
Quality you can see
Cycle System and Urinary Duo are formulated and manufactured by a laboratory in France's Loire Valley. Cramp Patch is formulated in France and manufactured in the United States.
95% curcuminoids. 2.5% rosmarinic acid. 30% PACs. 95% piperine. AKBA-enriched boswellia. P5P instead of pyridoxine. We specify what the extract has to contain, not just the plant it came from.
No proprietary blends. Every ingredient and every milligram is printed, per capsule and per patch, so you can compare it against anything else you are considering.
Every supplement batch is screened for heavy metals by ICP-MS and for microbial contamination to European Pharmacopoeia methods. Vitamins are measured by HPLC, magnesium by ICP-MS, the probiotic by plate count. A batch outside specification does not ship.
A bottle exposes every remaining capsule each time it opens. A blister keeps moisture, air and light out of each dose until you press it through. That matters most for live cultures, and it makes a short routine easy to carry.
Questions
Because each Kaia Relief product is formulated as a complete system, not a collection of single ingredients copied from separate trials. Published studies usually test one ingredient at a time, over a short period. Our amounts are chosen in the context of the whole formula, for repeat use and tolerability. Where the pack allows it, some products include a higher labeled use for harder days.
Your body needs different support at 8 AM and at 10 PM. The Day capsule focuses on comfort, mood and daily function. The Night capsule focuses on calm, recovery and sleep. An adaptogen that supports daytime energy does not belong in a sleep formula, and a muscle relaxant does not belong in your morning capsule.
Take Cycle System only during its nine-day window: the seven days before your period and the first two days of it. It is not meant for daily use through the month. Urinary Duo is for short-term use, up to seven days in a row. Follow each product's directions, and do not take more to try to get faster results.
Yes. The products are designed to work together, and Cramp Patch can be used alongside any of the capsules. If you take other medications or supplements, check with your healthcare provider.
Every capsule shell is HPMC, a plant-based material. No gelatin and no animal-derived ingredients. The capsules contain no gluten, dairy, soy, nuts or eggs. If you have a specific allergy, check the full ingredient list on the label or contact us.
We follow the published literature. If new human trials change the picture for an ingredient we use, we update this page and, if warranted, the formula.
Lab results
Certificates of Analysis for Cycle System and Urinary Duo, how we build and test every formula, and a straight answer on what we cannot test yet.
See the lab resultsRelief without compromise
Most complete for PMS
Cycle System Day + Night with Cramp Patch. Cramps, bloating, water retention, irritability and restless nights, covered morning, evening and in the moment.
$52 one-time
Shop the PMS Bundle
Looking for urinary support?
Urinary Duo
Botanical + Probiotic capsules, individually blister-sealed, for a routine of up to seven days.
$34 one-time
Your first order is covered by our 30-day first-order guarantee. View terms
Here for PMS and cramps?
*These statements have not been evaluated by the Food and Drug Administration. Cycle System and Urinary Duo are dietary supplements and are not intended to diagnose, treat, cure, or prevent any disease. Cramp Patch is for external use only. Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition. Ingredient research describes published studies of individual ingredients, not studies of Kaia Relief products.
